Electronic Theses and Dissertations





Document Type


Degree Name

Master of Science


Clinical Nutrition

Committee Chair

Marie van der Merwe

Committee Member

Richard Bloomer

Committee Member

Andrew Liu


The goal was to determine if a high fat diet given in a time restricted fashion can protect against obesity and inflammatory mediators. 12 week old C57BL/6 male mice were assigned to either a standard chow diet or a diet containing 45% fat. The high fat diet was provided ad libitum or in a time restricted fashion, either during the first of the second half of the active phase for 8 weeks. Time restricted meal intake reduced body mass gain, adiposity, glucose intolerance and cholesterol levels in mice fed a high fat diet. Mice fed a high fat diet, even on a time restricted meal pattern, resulted in increased tumor necrosis factor-a, fatty liver development and adipocyte hypertrophy suggesting time restricted feeding can protect against obesity, but does not protect against inflammation. These results suggest that a high fat diet can induce inflammation even in the absence of weight gain.


Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.