Electronic Theses and Dissertations

Identifier

4951

Date

2017

Document Type

Thesis

Degree Name

Master of Public Health

Major

Public Health

Concentration

Epidemiology

Committee Chair

Matthew Smeltzer

Committee Member

Vikki Nolan

Committee Member

Meredith Ray

Committee Member

Xinhua Yu

Abstract

Hypodiploid ALLis a rare subtype of ALL that is classified as having chromosomal abnormalities in leukemic cells, resulting in cells that have less than forty-six chromosomes. Poor clinical outcomes have been identified in patints with hypodiploid ALL; however, the influence of harboring a TP53 germline mutation in this rare subtype has not been previously studied. This study aims to determine if patients with hypodiploid ALL who harbor a TP53 germline mutation have a worse clinical outcome compared to patients with hypodiploid ALL who do not harbor a TP53 germline mutation. This analysis includes 42 hypodiploid ALLpatients, 18-years-old or younger, from St. Jude Children's Research Hospital. Patients with hypodiploid ALL who harbor a TP53 germline mutation have a decreased overall survival (p = 0.0018), have an increased risk of experiencing a relapse occurence (p = 0.0069), and developing a secondary malignancy (p = 0.0442).

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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