Date of Award
Master of Public Health
Hypodiploid ALLis a rare subtype of ALL that is classified as having chromosomal abnormalities in leukemic cells, resulting in cells that have less than forty-six chromosomes. Poor clinical outcomes have been identified in patints with hypodiploid ALL; however, the influence of harboring a TP53 germline mutation in this rare subtype has not been previously studied. This study aims to determine if patients with hypodiploid ALL who harbor a TP53 germline mutation have a worse clinical outcome compared to patients with hypodiploid ALL who do not harbor a TP53 germline mutation. This analysis includes 42 hypodiploid ALLpatients, 18-years-old or younger, from St. Jude Children's Research Hospital. Patients with hypodiploid ALL who harbor a TP53 germline mutation have a decreased overall survival (p = 0.0018), have an increased risk of experiencing a relapse occurence (p = 0.0069), and developing a secondary malignancy (p = 0.0442).
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Liddle, Victoria Danielle, "Haboring a TP53 Germline Mutation: Assessing Clinical Outcomes In Patients With Hypodiploid Acute Lymphoblastic Leukemia" (2017). Electronic Theses and Dissertations. 1652.