Electronic Theses and Dissertations

Identifier

6012

Date

2017

Document Type

Thesis

Degree Name

Master of Public Health

Major

Public Health

Concentration

Epidemiology

Committee Chair

Vikki Nolan

Abstract

Over half of childhood Acute Lymphoblastic Leukemia (ALL) survivors will suffer from one or more treatment-related medical conditions in their lifetime, many of which are known risk factors for diabetes. This study aims to determine the prevalence and potential risk factors of diabetes among ALL survivors from the St. Jude Lifetime Cohort (SJLIFE). We performed a retrospective-cohort analysis of 1041 SJLIFE 10-year survivors of ALL compared to 368 controls. Risk factors associated with increased risk of type 2 diabetes (T2DM) in survivors included: drug-induced diabetes (OR 4.98, 95% CI 2.59-9.58), obese/overweight BMI (OR 7.02, 95% CI 2.45-20.07; OR 3.26, 95% CI 1.03-10.23), and increasing age (OR 1.04, 95% CI 1.01-1.08). Survivors were also more likely to suffer from pre-diabetes (OR 1.33, 95% CI 1.06-1.67) and T2DM (OR 2.03 95% CI 1.09-2.83) compared to controls, highlighting the importance of surveillance and early interventions in SJLIFE survivors of childhood ALL.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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