Electronic Theses and Dissertations
Identifier
6050
Date
2017
Document Type
Thesis
Degree Name
Master of Science
Major
Mechanical Engineering
Concentration
Materials Science
Committee Chair
Gladius Lewis
Committee Member
Ebrahim Asadi
Committee Member
Steven Wayne
Abstract
It has been postulated that the high temperature reached during the polymerization of acrylic bone (for some brands, as high as 85 oC) (Tmax) may cause thermal necrosis of tissues close to the implant. In the present work, two methods to reducing Tmax were studied: change to the composition of the cement powder (by addition of 5-25 wt./wt.% microencapsulated phase change material) and a change to the composition of the cement liquid (by addition of a 1-3 vol./vol.% chain-stopping agent, namely, dodecyl mercaptan). The control cement was a commercially-available gentamicin-loaded brand. All cements were vacuum mixed. Eight other clinically-relevant properties of the cement were determined and compared to those of the control cement. While each method led to significant decreases in Tmax, the effect on the other cement properties varied to different degrees. Overall, the cements containing 2 vol./vol.% DDM and 3 vol./vol.% DDM may have the greatest potential to being viable alternatives to the control cement.
Library Comment
Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Recommended Citation
McKee, Robert Baker, "Influence two Compositional Changes on In Vitro Properties of an Antibiotic-Loaded Acrylic Bone Cement" (2017). Electronic Theses and Dissertations. 1738.
https://digitalcommons.memphis.edu/etd/1738
Comments
Data is provided by the student.