Date of Award
Master of Public Health
The risk of infection associated with subcutaneous port (SQP) placement in patients with neutropenia remains unclear. We reviewed the rate of early infectious complications (<30 days) following SQP placement in pediatric oncology pateints with /without neutropenia (absolute neutrophil count (ANC) <500/mm3.Baseline characteristics and infectious complications were compared between groups using univariable and multivariable analysis.A total of 614 SQP were placed in 542 patients. Compared to non-neutropenic patients, those with neutropenia were more likely to have leukemia (94% vs 50%), pre-operative fever (22% vs 5%), pre-operative infection (19% vs 9%), and were younger (81 vs 109 months) (p values <0.01).After adjusting for fever and underlying-disease there was a non-significant association between neutropenia and early post operative infection (OR 2.41, 95% CI 0.82-7.18, p=0.116). Only pre-operative fever was a predictor of infection (OR 6.09, 95% CI 2.08-17.81, p=0.564).Neutropenia may not be a predictor of early postoperative infection following SQP placement.
Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
VanHouwelingen, Lisa Taylor , MD, "Neutropenia at the Time of Subcutaneous Port Insertion May Not be a Risk Factor for Early Infectious Complications in Pediatric Oncology Patients." (2017). Electronic Theses and Dissertations. 1786.