"Comparison of Dietary and Caloric Restriction Models on Insulin Sensit" by Jade Leanna Caldwell
 

Electronic Theses and Dissertations

Identifier

6141

Date

2018

Document Type

Thesis

Degree Name

Master of Science

Major

Health and Sport Science

Concentration

Exercise, Sport & Movement Sci

Committee Chair

Richard Bloomer

Committee Member

Melissa Puppa

Committee Member

Marie van der Merwe

Abstract

Background: Various forms of fasting can result in improvements in insulin sensitivity. Objective: Compare the effects of various fasting models on measures of insulin sensitivity in young male C57BL/6 mice. Methods: 60 mice were assigned to the following groups: HF, CHOW, SWITCH, DF, CR, TRF, and ADF for 8 weeks, following a 6 week lead-in period of ad libitum HF consumption. Fasting blood glucose (mg/dL) and insulin (ng/mL) were measured and HOMA-IR, determined. Glucose tolerance tests were performed to determine glucose clearance pre- and post-intervention. Results: Compared to the HF ad libitum group, all groups displayed significantly lower fasting glucose, insulin, and HOMA-IR, as well as improved glucose tolerance. Additionally, ADF displayed the lowest fasting blood glucose and glucose AUC. Conclusion: All investigated fasting protocols may improve fasting glucose, insulin, and HOMA-IR. ADF may allow for ideal fasting blood glucose and clearance of glucose loads following a glucose challenge.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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