Electronic Theses and Dissertations

Identifier

6141

Date

2018

Document Type

Thesis

Degree Name

Master of Science

Major

Health and Sport Science

Concentration

Exercise, Sport & Movement Sci

Committee Chair

Richard Bloomer

Committee Member

Melissa Puppa

Committee Member

Marie van der Merwe

Abstract

Background: Various forms of fasting can result in improvements in insulin sensitivity. Objective: Compare the effects of various fasting models on measures of insulin sensitivity in young male C57BL/6 mice. Methods: 60 mice were assigned to the following groups: HF, CHOW, SWITCH, DF, CR, TRF, and ADF for 8 weeks, following a 6 week lead-in period of ad libitum HF consumption. Fasting blood glucose (mg/dL) and insulin (ng/mL) were measured and HOMA-IR, determined. Glucose tolerance tests were performed to determine glucose clearance pre- and post-intervention. Results: Compared to the HF ad libitum group, all groups displayed significantly lower fasting glucose, insulin, and HOMA-IR, as well as improved glucose tolerance. Additionally, ADF displayed the lowest fasting blood glucose and glucose AUC. Conclusion: All investigated fasting protocols may improve fasting glucose, insulin, and HOMA-IR. ADF may allow for ideal fasting blood glucose and clearance of glucose loads following a glucose challenge.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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