Electronic Theses and Dissertations
Identifier
6351
Date
2018
Document Type
Dissertation
Degree Name
Doctor of Philosophy
Department
Counseling Psychology
Committee Chair
Suzanne Lease
Committee Member
Douglas Strohmer
Committee Member
Chrisann Schiro-Geist
Committee Member
Brandon Baughman
Abstract
Background: While individuals diagnosed with Parkinsons disease (PD) often experience cognitive deficits, depression, and fatigue, the relationships among these non-motor sequelae throughout the progression of the disease are unclear. Objective: To examine the relationships among disease severity, depression, and fatigue and investigate the independent contributions of depression and fatigue to a composite measure of cognitive functioning, when controlling for disease severity in PD patients. Methods: A mixed retrospective and prospective sample of PD patients completed a comprehensive neuropsychological battery, as well as self-report measures of depression and fatigue. Cognitive functioning was represented by a summary statistic, or cognitive impairment index (CII). A hierarchal linear regression model, controlling for disease severity, examined the unique contributions of depression and fatigue on cognitive functioning. A Pearson correlation examined the relationship between depression and fatigue. Results: At step one, disease severity significantly contributed to the model, F(1, 41) = 48.06, p < .001, accounting for 52.8% of the variance in cognitive functioning. Introduction of depression and fatigue explained an additional 7.2% of the variance and this change in R2 was significant F(2,39) = 4.68, p < 0.05. Only depression continued to be a significant contributor beyond disease severity, t = 2.21, = 0.24, p < 0.05 and the change in the model was significant, F(1, 40) = 4.88, p < 0.05, R2 change = 0.05Conclusions: Findings suggest that depression is uniquely associated with cognitive functioning observed in PD patients independent of disease severity or level of fatigue. Interventions targeted towards depression may improve cognitive functioning.
Library Comment
Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Recommended Citation
Brett, Benjamin L., "Neurocognitive Functioning in Parkinson's Disease Patients: Assessing the Unique Contributions of Depression and Fatigue While Controlling for Disease Severity" (2018). Electronic Theses and Dissertations. 1926.
https://digitalcommons.memphis.edu/etd/1926
Comments
Data is provided by the student.