Evaluating Elution & Mechanical Characteristics of a Calcium Sulfate Bone Graft Substitute Containing Amphotericin B, Cefazolin, or Vancomycin

Identifier

275

Author

Sami Ali Helou

Date

2011

Document Type

Thesis

Degree Name

Master of Science

Major

Biomedical Engineering

Committee Chair

Joel D Bumgardner

Committee Member

Warren O Haggard

Committee Member

Eugene Charles Eckstein

Abstract

Problem: Osteomyelitis is a major infection that destroys bone. Treatment of the infection involves use of an injectable calcium sulfate material. This material may be used for the local delivery of antibiotics at the site of infection to improve clinical treatment. Studies are needed to determine effects of added antibiotics on injectable calcium sulfate material properties.Hypothesis: Antibiotic-loaded injectable calcium sulfate will retain their chemical/mechanical properties, and elution of the antibiotics will remain large enough to inhibit any microbial infections.Aims:1. Characterize effects of mixing amphotericin B, cefazolin, or vancomycin on calcium sulfate's properties.2. Measure elution/dissolution profiles in vitro.3. Evaluate eluents ability to inhibit bacterial growth.Conclusion: There were no adverse effects on the material's characteristics. Cefazolin and vancomycin were high enough levels to inhibit in vitro growth of S. aureus.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

Recommended Citation

Helou, Sami Ali, "Evaluating Elution & Mechanical Characteristics of a Calcium Sulfate Bone Graft Substitute Containing Amphotericin B, Cefazolin, or Vancomycin" (2011). Electronic Theses and Dissertations. 209.
https://digitalcommons.memphis.edu/etd/209