Electronic Theses and Dissertations

Identifier

6653

Date

2020

Document Type

Thesis

Degree Name

Master of Science

Major

Biomedical Engineering

Committee Member

Joel Bumgardner

Committee Member

Jessica Amber Jennings

Committee Member

Tomoko Fujiwara

Abstract

The aim of this work was to take advantage of the electrospray technology and the osteocompatibility of both chitosan and calcium phosphate (CaP) to fabricate chitosan coatings loaded with CaP nanoshell particles. The key electrospray parameters of capillary diameter, voltage, and pressure were identified and adjusted for creating uniform chitosan-CaP coatings on titanium surfaces. Coatings containing from 0 to 1 wt% CaP particles to chitosan mass were electrosprayed on to silanated titanium to create composite coatings bonded to the metal surface. Scanning electron microscope (SEM) and energy dispersive X-ray spectroscopy (EDS) showed that CaP particles were homogenously distributed throughout the chitosan coating. Mechanical tensile testing demonstrated that there was no statistically significant loss of coating adhesion strength up to 1.0 wt% incorporation of CaP particles. Furthermore, the incorporation of CaP particles was shown to support growth of bone cells on the coating. We have demonstrated that CaP particles can successfully be incorporated into electrosprayed chitosan coating.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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