Electronic Theses and Dissertations

Liang Li

Date

2021

Document Type

Dissertation

Degree Name

Doctor of Philosophy

Department

Public Health

Committee Chair

Hongmei Zhang

Committee Member

Wilfried Karmaus

Committee Member

Yu Jiang

Committee Member

Syed Arshad

Abstract

Previous studies have shown the association of age at puberty onset with lung function later in life, and the relationship of newborn DNA methylation (DNAm) with childhood asthma, However, the roles of height growth and DNAm play between age of pubertal events and young adulthood lung function and how DNAm at birth is associated with asthma acquisition later in life are unknown. This dissertation represents an effort to tackle these knowledge gaps. A discovery cohort, the Isle of Wight birth cohort (IOWBC), and a replication cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort are included in the study.The dissertation includes three carefully designed studies. In the first study, I assessed the mediation effects of height growth on the association of age of pubertal onset with post-adolescence lung function parameters using path analysis. We found that age at menarche and body hair growth had a positive indirect association (via height growth) with FVC or FEV1 at age 26 years in females (all p-values

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to ProQuest

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