Electronic Theses and Dissertations

Date

2023

Document Type

Thesis

Degree Name

Master of Science

Department

Biomedical Engineering

Committee Chair

J. Amber Jennings

Committee Member

Joel D Bumgardner

Committee Member

Tomoko Fujiwara

Abstract

Infections are a common post-operative ailment for patients who have received a dental implant or biomedical device. These infections can be further complicated with biofilm development, leading to systemic infection or antibiotic resistance. Local drug delivery has recently increased in popularity due to its advantages in treating and preventing infection during wound healing while avoiding the common side effects of systemic drugs. Local drug delivery systems also have advantages for complex wounds, especially those with local vasculature damage. Hydroxyapatite is a natural bioceramic that can be used as a local delivery system due to its biocompatibility and remineralization potential. Previous research has suggested that unsaturated fatty acids, such as 2-heptylcyclopropane-1-carboxylic acid (2CP), disperse and inhibit biofilm formation. In this project, the release profile, antimicrobial properties, and cytocompatibility of 2CP-loaded hydroxyapatite coupons were assessed, and a hydroxyapatite delivery system was created for 2CP that inhibits biofilm-associated dental infections while remaining non-cytotoxic.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to ProQuest.

Notes

Open Access

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