Master of Science
J. Amber Jennings
Joel D Bumgardner
Infections are a common post-operative ailment for patients who have received a dental implant or biomedical device. These infections can be further complicated with biofilm development, leading to systemic infection or antibiotic resistance. Local drug delivery has recently increased in popularity due to its advantages in treating and preventing infection during wound healing while avoiding the common side effects of systemic drugs. Local drug delivery systems also have advantages for complex wounds, especially those with local vasculature damage. Hydroxyapatite is a natural bioceramic that can be used as a local delivery system due to its biocompatibility and remineralization potential. Previous research has suggested that unsaturated fatty acids, such as 2-heptylcyclopropane-1-carboxylic acid (2CP), disperse and inhibit biofilm formation. In this project, the release profile, antimicrobial properties, and cytocompatibility of 2CP-loaded hydroxyapatite coupons were assessed, and a hydroxyapatite delivery system was created for 2CP that inhibits biofilm-associated dental infections while remaining non-cytotoxic.
Dissertation or thesis originally submitted to ProQuest.
Montgomery, Emily Coleman, "Evaluation of Fatty Acid Coated Hydroxyapatite for Biofilm-Associated Infection Prevention Following Dental Implantation" (2023). Electronic Theses and Dissertations. 3309.