Effect of Sex on the Development of Non-Alcoholic Fatty Liver Disease During the Progression of Metabolic Syndrome

Author

Noah C. Wallace

Date

2024

Document Type

Thesis

Degree Name

Master of Science

Department

Health Studies

Committee Chair

Melissa Puppa

Committee Member

Marie van der Merwe

Committee Member

Aaryani Sajja

Abstract

Background: There is an association between sex and the prevalence of Metabolic Syndrome (MetS) and Non-Alcoholic Fatty Liver Disease (NAFLD). Objective: Determine the effects of sex and high fat/sucrose diet on the development of MetS and NAFLD. Methods: 30 male and 30 female C57BL/6 mice were place on one of three diets: High Fat (45% Fat), High Sugar (60% Sucrose), and Control. Results: Male mice on a High Fat diet showed the greatest weight gain amongst all the group as well as demonstrating earlier signs of glucose intolerance. Only those placed on a high sugar diet had indications of liver fibrosis as apparent with Masson’s Trichrome staining. Sex affected protein expression of SREBP-1c and ChREBP. Fasn and Glut4 showed no difference. Conclusion: There are diet and sex differences in the signaling for liver de novo lipogenesis that may contribute to the dimorphic development of NAFLD and MetS.

Comments

Data is provided by the student.”

Library Comment

Dissertation or thesis originally submitted to ProQuest.

Notes

Open Access

Recommended Citation

Wallace, Noah C., "Effect of Sex on the Development of Non-Alcoholic Fatty Liver Disease During the Progression of Metabolic Syndrome" (2024). Electronic Theses and Dissertations. 3462.
https://digitalcommons.memphis.edu/etd/3462