Electronic Theses and Dissertations Archive

Date

2026

Document Type

Dissertation

Degree Name

Doctor of Philosophy

Department

Chemistry

Committee Chair

Tomoko Fujiwara

Committee Member

Charles Garner

Committee Member

Joel Bumgardner

Committee Member

Michael Brown

Committee Member

Timothy Brewster

Abstract

This dissertation outlines the design, synthesis, and characterization of oxaliplatin-derived Pt(IV) prodrugs consisting of biologically active ligands. The stability and coordination behavior of oxaliplatin and a synthesized Pt(IV) derivative are investigated in an aqueous/organic mixed solution. Additionally, cytotoxicity of the compounds was tested using two human osteosarcoma cell lines, MG-63 and SK-ES-1. Notably, the tested drugs exhibited comparable or increased cytotoxicity compared to oxaliplatin. Another aspect of this research outlines the development and optimization of a triple-network hydrogel for the encapsulation and release of the hydrophobic drug Simvastatin. The hydrogel exhibited mechanical stability, biocompatibility, and biodegradability. Furthermore, it details the development of a multi-responsive smart hydrogel for controlled drug delivery.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to ProQuest/Clarivate.

Notes

Open Access

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