Electronic Theses and Dissertations





Document Type


Degree Name

Doctor of Philosophy


Biomedical Engineering

Committee Chair

John Leicester Williams

Committee Member

Eddie L Jacobs

Committee Member

Audrey R Zucker-Levin

Committee Member

William Mihalko


The anterior cruciate ligament (ACL) is the most commonly injured knee ligament with approximately 250,000 ACL tears diagnosed each year in the United States which leads to an estimated 150,000 ACL reconstructions annually. The primary goal of ACLreconstruction is to restore stability to the knee and return the patient to their prior level of activity. However, it has been reported that abnormal motion and/or forces at the knee due to ACL reconstruction could lead to early-onset knee osteoarthritis. It is hypothesized that alterations in knee joint kinematic and kinetic measurements after ACLreconstruction can be characterized when comapred to a control population. The current work describes how the ACL reconstruction subjects' three-dimensional knee joint angles and moments during gait were compared to control subjects, and it explores the knee kinematics and ground reaction forces during a squat activity. This work also discusses the theory behind musculoskeletal modeling and applies an advanced model to examine the tibiofemoral compressive forces and predicted muscle forces during gait of the ACLreconstructed subjects compared to BMI-matched control subjects. These studies showed the capabilities of using musculoskeletal modeling along with principal component analysis to identify ACL reconstruction subjects who displayed knee kinematic and kinetic measurements which fell outside of normal values. This type of analysis may lead to a diagnostic tool for detecting individuals at risk for developing early osteoarthritis after ACL reconstruction. This would allow these individuals to receive early intervention in the hopes of mitigating knee osteoarthritis.


Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.