Date of Award
Master of Science
Health and Sport Science
Exercise and Sport Science
Richard J. Bloomer
Randal K. Buddington
While RONS are produced as part of normal metabolism, excess production can occur in response to stressors, such as physical exercise and ingestion of excess nutrients (e.g., saturated fat). Over time this may lead to an up-regulation in antioxidant enzyme activity, in an attempt to protect cells. The purpose of this investigation was to determine if an increase in antioxidant enzyme activity is observed following repeatedingestion of high fat meals. Sixteen healthy men consumed10 high fat milkshakes over a 3+ weekperiod. Blood was taken from subjects on the firstday of each week (before andfor 4 hours after milkshake ingestion) and analyzed for oxidative stress biomarkers. Repeated high-fat feeding didnot result in anyup-regulation in antioxidant enzymatic activity or attenuation in oxidative stress. Thesedata indicate that the RONS production associated with repeated consumption of high-fat meals does not induce an adaptive response within the blood antioxidant defense system.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Harvey, Innocence Christianna, "The Role of High-fat Feeding on the Up-regulation in Antioxidant Enzymes: A Potential" (2013). Electronic Theses and Dissertations. 665.