Electronic Theses and Dissertations

Identifier

964

Date

2013

Document Type

Thesis

Degree Name

Master of Science

Major

Electrical and Computer Engr

Concentration

Computer Engineering

Committee Chair

Mohammed Yeasin

Committee Member

Ramin Homayouni

Committee Member

Bashir Morshed

Abstract

This thesis presents the design and impementation of a system to find the top ranked relevant Medline citations with hyperlinks. The iput to the systm is a network of semantically related drug-diseases associations obtained by the DDNet. A fully functional system can be used for generation/validation of hypothesis or to find most relevant literature based on user input in birdging gap between the generation and utilzation of biomedical literature. Such a system may also have an impact in identification of "drug targets" and may open new avenues for "drug repositioning" in clinical and translational research. Multi-Layered LSA model is implemented to filter the voluminous publications and find top ranked literature. In particular, a Local Latent Semantic Analysis (LLSA) with query-based sampling of abstracts was used to build model that is relatively free from "garbage-in garbage-out syndrome". The current implementation ensures that the system is efficient, scalable and relatively free from systemic bias. Also, the concept of mapping ontologies was adopted to develop best suited dictionary to find the domain specific "crisp associaions" and relevant results. A reverse ontology mapping was used to create a network from semantically relevant associations. In addition, a web service application was developed to query the system and visualize the computed network of associations along with their most relevant publications' links in a way that is easy to interact. A pilot study was conducted to evaluate the performance of system using both subjective and objective measures.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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