Electronic Theses and Dissertations

Identifier

1027

Jordan Leumas

Date

2014

Document Type

Thesis

Degree Name

Master of Science

Major

Biology

Committee Chair

Theodore Kent Gartner

Committee Member

Judith Cole

Committee Member

Carlos Estrano

Committee Member

Richard Smith

Abstract

Sickle Cell Disease (SCD) is one of the most common severe monogenic disorders in the world. The disease causes severe pain, inflammation, tissue ischemia, and bone damage. The Townes mouse model of SCD has been useful in studying many of the pathophysiologies of the disease but has not been evaluated as a model of SCD-induced bone abnormalities. The data presented in this study demonstrate that SCD causes bone abnormalities in the Townes mouse model similar to those present in humans. This study also evaluated the antioxidant agent N-acetyl-L-cysteine (NAC) as a potential therapeutic agent for the progression of bone abnormalities in SCD mice.

Comments

Data is provided by the student.

Library Comment

Dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.

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