Date of Award
Master of Science
Theodore Kent Gartner
Sickle Cell Disease (SCD) is one of the most common severe monogenic disorders in the world. The disease causes severe pain, inflammation, tissue ischemia, and bone damage. The Townes mouse model of SCD has been useful in studying many of the pathophysiologies of the disease but has not been evaluated as a model of SCD-induced bone abnormalities. The data presented in this study demonstrate that SCD causes bone abnormalities in the Townes mouse model similar to those present in humans. This study also evaluated the antioxidant agent N-acetyl-L-cysteine (NAC) as a potential therapeutic agent for the progression of bone abnormalities in SCD mice.
dissertation or thesis originally submitted to the local University of Memphis Electronic Theses & dissertation (ETD) Repository.
Leumas, Jordan, "Characterization of Bone Abnormalities in Townes Sickle Cell Mice" (2014). Electronic Theses and Dissertations. 869.