Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir

Authors

• Samuel G. Wittekind, University of Cincinnati
• Catherine C. Allen, University of Cincinnati
• John L. Jefferies, University of Cincinnati
• Mantosh S. Rattan, University of Cincinnati
• Peace C. Madueme, University of Cincinnati
• Bre Ann N. Taylor, University of Cincinnati
• Ryan A. Moore, University of Cincinnati

Abstract

Dystrophic myocardial calcification occurs in the setting of myocardial injury and normal serum calcium. We present a case of a neonate with prominent dystrophic calcification and severe left ventricular systolic dysfunction in the setting of enterovirus myocarditis. These findings are superbly illustrated by multiple imaging modalities. The patient was treated with the novel antiviral, pocapavir, in addition to a standard heart failure regimen. The dystrophic calcification persisted but the left ventricle remodeled significantly. To our knowledge, this is the first reported use of pocapavir for this indication. The literature regarding enterovirus myocarditis and pocapavir is briefly reviewed.

Publication Title

Journal of Investigative Medicine High Impact Case Reports

Recommended Citation

Wittekind, S., Allen, C., Jefferies, J., Rattan, M., Madueme, P., Taylor, B., & Moore, R. (2017). Neonatal Enterovirus Myocarditis With Severe Dystrophic Calcification: Novel Treatment With Pocapavir. Journal of Investigative Medicine High Impact Case Reports, 5 (3) https://doi.org/10.1177/2324709617729393