Outcomes of Ultrafiltration in community-based hospitals

Authors

• Viswanath R. Chinta, HCA Medical Center Hospital
• Neelima P. Theella, HCA Medical Center Hospital
• Joel M. Raja, University of Tennessee Health Science Center
• Aranyank Rawal, University of Tennessee Health Science Center
• Anandbir Bath, Michigan State University
• David Jones, University of Tennessee Health Science Center
• Atif Ibrahim, North Mississippi Medical Center
• Abdul Aziz A. Asbeutah, University of Tennessee Health Science Center
• Adedayo A. Adeboye, University of Tennessee Health Science Center
• Oguz Akbilgic, Wake Forest University School of Medicine
• Rami N. Khouzam, Grand Strand Medical Center
• James J. Stamper, UAB Division of Cardiovascular Disease
• John L. Jefferies, University of Memphis

Abstract

Objective: We sought to examine outcomes of ultrafiltration in real world community-based hospital settings. Background: Ultrafiltration (UF) is an accepted therapeutic option for advanced decompensated heart failure (ADHF). the feasibility of UF in a community hospital setting, by general cardiologists in a start-up program had not been objectively evaluated. Methods: We retrospectively analyzed the first-year cohort of ADHF patients treated with UF from 10/1/2019 to 10/1/2020, which totaled 30 patients, utilizing the CHF Solutions Aquadex FlexFlow™ System with active UF rate titration. Results: Baseline patient characteristics were similar to RCTs: mean age 63, 73 % male; 27 % female; 53 % Caucasian; 47 % African American; 77 % had LVEF ≤ 40. The baseline mean serum creatinine (Cr) was 1.84 ±0.62 mg/dL, mean GFR of 36.95 ±9.60 ml/min. HF re-admission rates were not significantly different than prior studies (17.2 % at 30 d, 23.3 % at 60 d, but in our cohort, per patient HF re-admission rates were reduced significantly by 60 d (0.30 p = 0.017). Conclusion: Our analysis showed success with UF in mainstream setting with reproducible results of significant volume loss without adverse renal effect, mitigation of recurrent Hdmissions, and remarkable subjective clinical benefit.

Publication Title

Current Problems in Cardiology

Recommended Citation

Chinta, V., Theella, N., Raja, J., Rawal, A., Bath, A., Jones, D., Ibrahim, A., Asbeutah, A., Adeboye, A., Akbilgic, O., Khouzam, R., Stamper, J., & Jefferies, J. (2024). Outcomes of Ultrafiltration in community-based hospitals. Current Problems in Cardiology, 49 (10) https://doi.org/10.1016/j.cpcardiol.2024.102716