Refractory dilated cardiomyopathy associated with metastatic neuroblastoma
Abstract
A 2-year-old African American male presented with heart failure and an abdominal mass. Computerized tomography (CT) scan revealed a 7 cm adrenal lesion, confirmed as poorly differentiated neuroblastoma (NB). CT and meta-iodobenzoguanidine (MIBG) scans identified multiple metastases, but cardiac MIBG imaging was absent. Cardiac ejection fraction (EF) was 8% with 7% shortening fraction. The patient underwent six cycles of chemotherapy and investigational immunotherapy. Cardiac function improved to 26% EF. However, the tumor proved unresponsive to treatment. The patient died from stage IV congestive heart failure (CHF) and progressive NB. Autopsy confirmed dilated cardiomyopathy with endocardial fibroelastosis. Pediatr Blood Cancer. © 2010 Wiley-Liss, Inc.
Publication Title
Pediatric Blood and Cancer
Recommended Citation
Carlson, P., Jefferies, J., Kearney, D., & Russell, H. (2010). Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. Pediatric Blood and Cancer, 55 (4), 736-738. https://doi.org/10.1002/pbc.22569
