Activity of daily living for Morquio A syndrome

Abstract

Purpose: An increase in the 1000/500 Hz frequency amplitude ratio (FARthe cervical and ocular vestibular evoked myogenic potentials (cVEMP oVEMP, respectively) may serve as a potential biomarker for diagnosMeniere’s disease (MD). However, the aging process can also result in increased FAR for VEMPs. In older patients, distinguishing whether changeVEMP FAR are due to MD or aging processes becomes difficult. We aiminvestigate the effects of age on VEMP FARs and establish a FAR-normrange for different age groups. Method: cVEMP and oVEMP were recorded from a total of 106 participgrouped as young, middle-aged, and older adults using air-conducted tbursts at 500, 750, and 1000 Hz at 125 dB pSPL. The FAR was calculatthe cVEMP and oVEMP for the following frequencies: FAR1 = 1000/FAR2 = 1000/750, and FAR3 = 750/500. Results: A significant age-related effect was observed on the cVEMP FAlthough the oVEMP FAR showed an increasing trend with age, it was notistically significant. Age-based normative FAR values are provided. Conclusions: Drawing from the normative FAR from this study, there is dence that the existing MD diagnostic criteria would misidentify a considernumber of older adults. Therefore, to reduce false positives, we recommenmore stringent cVEMP and oVEMP FAR criterion in older adults.

Publication Title

American Journal of Audiology

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