Characterization of isoniazid incorporation into chitosan-poly(aspartic acid) nanoparticles

Authors

• Carmen L. Zegarra-Urquia, Universidad Nacional Mayor de San Marcos
• Julio Santiago, Universidad Nacional Mayor de San Marcos
• Joel D. Bumgardner, University of Memphis
• Alexander K. Goroncy, College of Engineering and Physical Sciences
• José Vega-Baudrit, Centro Nacional de Alta Tecnología (CENAT)
• Claudia A. Hernández-Escobar, Centro de Investigacion en Materiales Avanzados
• E. Armando Zaragoza-Contreras, Centro de Investigacion en Materiales Avanzados

Abstract

The incorporation of the drug Isoniazid (an anti-tuberculosis drug) into nanoparticles of polyelectrolyte chitosan-poly(aspartic acid) complexes was carried out by the ionotropic gelation technique, adding a sodium polyaspartate solution containing the drug to a chitosan solution in different proportions in a mass ratio (mg/mg) Isoniazid/Chitosan. This was confirmed by MALDI-TOF/MS, ESI/MS, FTIR, and UV-Vis. The lowest average particle diameter (PD), estimated by DSL, was 148.5 ± 1 nm corresponding to an Isoniazid/chitosan ratio (mg/mg) of 0.5:1. FE-SEM showed nanoparticles in the order of 100–300 nm; whereas AFM showed semi-spherical particle morphology.

Publication Title

International Journal of Polymeric Materials and Polymeric Biomaterials

Recommended Citation

Zegarra-Urquia, C., Santiago, J., Bumgardner, J., Goroncy, A., Vega-Baudrit, J., Hernández-Escobar, C., & Zaragoza-Contreras, E. (2024). Characterization of isoniazid incorporation into chitosan-poly(aspartic acid) nanoparticles. International Journal of Polymeric Materials and Polymeric Biomaterials, 73 (3), 190-199. https://doi.org/10.1080/00914037.2022.2145287