Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis?

Authors

• Charles D. Varnell, Cincinnati Children's Hospital Medical Center
• Stuart L. Goldstein, Cincinnati Children's Hospital Medical Center
• Donald L. Yee, Baylor College of Medicine
• Jun Teruya, Baylor College of Medicine
• Kirk E. Guyer, Indiana University South Bend
• Shakeel Siddiqui, Baylor College of Medicine
• John L. Jefferies, Cincinnati Children's Hospital Medical Center

Abstract

Our study was developed to ascertain reference ranges of 11-dehydrothromboxane B2 (11-dhTXB2) in the urine of healthy pediatric subjects. Urine samples were analyzed using the AspirinWorks™ assay that measures levels of 11-dehydrothromboxane B2. 128 individuals (2 months to 18 years) were identified as healthy and not receiving aspirin. When adjusted as picograms/milligrams urine creatinine, there was a negative correlation between age and level of 11-dehydrothromboxane B2 (P=0.0001). This study confirms a negative correlation between age and level of urinary 11-dehydrothromboxane B2 and provides a set of age-specific reference ranges.

Publication Title

Pediatric Blood and Cancer

Recommended Citation

Varnell, C., Goldstein, S., Yee, D., Teruya, J., Guyer, K., Siddiqui, S., & Jefferies, J. (2014). Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis?. Pediatric Blood and Cancer, 61 (11), 2074-2076. https://doi.org/10.1002/pbc.25089