Electrospun chitosan membranes loaded with raspberry ketone for guided bone regeneration applications

Abstract

Statement of Purpose: Electrospun chitosan membranes (ESCMs) have potential as a guided bone regeneration (GBR) material that can be used to protect bone graft spaces from infiltration of soft tissue into the bone graft site. The porous structure created by nanofibers in ESCMs allows communication between osseous and epithelial tissue compartments, as well as nutrient exchange while remaining cell occlusive. Raspberry ketone (RK) is a naturally occurring phenolic compound that has been reported to initiate differentiation of stem cells into osteoblasts [1]. The aim of this study was to examine the release of RK from the fibers, and evaluate the effects of RK on growth and osteo-differentiation of W20-17 mouse stromal cells.

Publication Title

Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

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