Electrospun tissue regeneration biomaterials for immunomodulation
Abstract
In situ tissue engineering aims to use acellular biomaterials and the body as a bioreactor to stimulate the regenerative capacity of autologous cells, tissues, and organs. Electrospinning is a popular fabrication technique for creating these biomaterials because it is a versatile, cost-effective approach that generates fibrous structures to mimic the native extracellular matrix. However, the success of the electrospun biomaterial in promoting functional, tissue regeneration is largely dependent on the immune response triggered upon implantation and the capacity to modulate it through the biomaterial design and interacting cell populations. In this chapter, we discuss electrospun biomaterials and immunomodulation, focusing on what is known about designing biomaterials to direct the immune response toward functional, tissue regeneration.
Publication Title
Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome
Recommended Citation
Fetz, A., Wallace, S., & Bowlin, G. (2021). Electrospun tissue regeneration biomaterials for immunomodulation. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome, 89-117. https://doi.org/10.1016/B978-0-12-821440-4.00003-7
