Intracranial dual-mode IVUS and hyperthermia using circular arrays
Abstract
In this study, we investigated the feasibility of using 3.5-Fr circular phased array IVUS catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: 1) by fitting a 3.5-Fr IVUS catheter through burr holes, for 20 MHz imaging, and 2) by testing a modified circular array for therapy potential with 18.5-MHz and 9.0 MHz CW excitation. The imaging transducer's performance was compared to our previous 9 MHz mechanical IVUS prototype. The therapy transducer was driven by CW electrical power, achieving temperature changes reaching +8°C at a depth of 2 mm in human glioblastoma tissue grown on the flank of a mouse. Further hyperthermia trials showed that resistive heating of the transducer was minimal producing a +2°C increase with CW excitation. © 2011 IEEE.
Publication Title
IEEE International Ultrasonics Symposium, IUS
Recommended Citation
Patel, V., Light, E., Herickhoff, C., Palmeri, M., Grant, G., Britz, G., Wilson, C., & Smith, S. (2011). Intracranial dual-mode IVUS and hyperthermia using circular arrays. IEEE International Ultrasonics Symposium, IUS, 2185-2188. https://doi.org/10.1109/ULTSYM.2011.0542
