Intracranial dual-mode IVUS and hyperthermia using circular arrays: Preliminary experiments
Abstract
In this study, we investigated the feasibility of using 3.5-Fr (3 Fr = 1 mm) circular phased-array intravascular ultrasound (IVUS) catheters for minimally invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility was demonstrated in two ways: (1) by inserting a 3.5-Fr IVUS catheter through skull burr holes, for 20 MHz brain imaging in the pig model, and (2) by testing a modified circular array for therapy potential with 18.5-MHz and 9-MHz continuous wave (CW) excitation. The imaging transducer's performance was superior to our previous 9-MHz mechanical IVUS prototype. The therapy catheter transducer was driven by CW electrical power at 18.5 MHz, achieving temperature changes reaching +8°C at a depth of 2 mm in a human glioblastoma grown on the flank of a mouse with minimal transducer resistive heating of +2°C. Further hyperthermia trials showed that 9-MHz CW excitation produced temperature changes of +4.5°C at a depth of 12 mm - a sufficient temperature rise for our long-term goal of targeted, controlled drug release via thermosensitive liposomes for therapeutic treatment of 1-cm-diameter glioblastomas. © Author(s) 2013.
Publication Title
Ultrasonic Imaging
Recommended Citation
Patel, V., Light, E., Herickhoff, C., Grant, G., Britz, G., Wilson, C., Palmeri, M., & Smith, S. (2013). Intracranial dual-mode IVUS and hyperthermia using circular arrays: Preliminary experiments. Ultrasonic Imaging, 35 (1), 17-29. https://doi.org/10.1177/0161734612469372
