New biaxial testing method for producing uniform and isotropic strains in membranes used as cell or tissue substrates

Abstract

A method is described for generating small (less than 0.4 percent) uniform and isotropic strains in thin elastomeric circular membranes used as substrates for cells or `man-made' biological tissues. The method keeps the membrane in the same plane during stretching, thereby minimizing possible fluid-related effects caused by movement of the membrane through the overlying tissue culture media. The method also allows for continual optical monitoring of cells or tissues during the stretching of the membrane.

Publication Title

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

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