1-Methyl-4-(methylamino)piperidine-platinum(II) adducts with DNA bases

Abstract

A series of platinum(II) monoadducts and diadducts of the type [PtII(mmap)LCl]NO3 and [PtII(mmap)L2](NO3)2 (where mmap = 1-methyl-4- (methylamino)piperidine and L = adenine, 9-methylguanine, 7-methylguanine, cytosine, or uracil) have been synthesized and characterized by elemental analyses and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. Two adjacent corners of the platinum plane were occupied by the two amino nitrogens of 1-methyl-4-(methylamino)piperidine and the other two positions were occupied by the chloride and nitrogen atoms of the DNA base in monoadducts and two nitrogen atoms of DNA bases in diadducts. © 2007 Taylor & Francis.

Publication Title

Journal of Coordination Chemistry

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