An improved method for the palladium-catalyzed amination of aryl iodides

Authors

M. H. Ali, Massachusetts Institute of Technology
S. L. Buchwald, Massachusetts Institute of Technology

Abstract

Aryl iodides are coupled with amines to give the corresponding arylamines in high yield in the presence of palladium, a suitable ligand, and NaOt-Bu. Functionalized aryl iodides give good yields of the corresponding arylamines when Cs2CO3 is substituted as the base.

Publication Title

Journal of Organic Chemistry

Recommended Citation

Ali, M., & Buchwald, S. (2001). An improved method for the palladium-catalyzed amination of aryl iodides. Journal of Organic Chemistry (8), 2560-2565. https://doi.org/10.1021/jo0008486