cis-1,4-Diaminocyclohexane-Pt(II) and -(IV) adducts with DNA bases and nucleosides

Abstract

A series of new platinum(II) and platinum(IV) adducts of type [P II(cis-1,4-DACH)LCl]NO3, where cis-1,4-DACH=cis-1,4-diaminocyclohexane, and L=9-ethylguanine, 1-methylcytosine, adenine, adenosine, cytosine, cytidine, guanine, and [Pt IV(cis-1,4-DACH)Ltrans-(X)2Cl]NO3, (where Y=hydroxo or acetato), were synthesized and characterized by elemental analysis, infrared spectroscopy, and 1H and 195Pt nuclear magnetic resonance spectroscopy. © 2003 Elsevier Inc. All rights reserved.

Publication Title

Journal of Inorganic Biochemistry

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