Development of an electrically addressable DNA-based aligned multi-walled carbon nanotube nanosensor
Abstract
This paper reports the design and fabrication of a biosensor based on aligned side-wall functionalized multi-walled carbon nanotubes with integrated single-strand DNAs (ssDNA). Due to their direction dependent physical properties and size, electrically conducting multi-wall carbon nanotubes (MWCNTs) with attached complementary ssDNA show promise to function as next-generation nanoscale sensors for numerous biosensing diagnostic applications. Hybridization kinetics between complementary and target ssDNA nucleotide base pairs results in a local charge generation between base pairs that is injected into the MWCNTs resulting in a change in MWCNT electrical characteristics. With the integration of ssDNA to the exterior surface of MWCNTs the possibility of fabricating a real-time biosensor that operates on a combination of change in electrical properties and nucleic acid testing (NAT) principles can be realized. ©2005 IEEE.
Publication Title
2005 5th IEEE Conference on Nanotechnology
Recommended Citation
Clendenin, J., Tung, S., Kim, J., Deaton, R., & Kotagiri, N. (2005). Development of an electrically addressable DNA-based aligned multi-walled carbon nanotube nanosensor. 2005 5th IEEE Conference on Nanotechnology, 853-856. https://doi.org/10.1109/NANO.2005.1500667
