Drimane-type sesquiterpenes from polygonum hydropiper

Abstract

One new drimane-type sesquiterpenoid, 3-angeloyloxy-7-epifutronolide (1), and one new natural product, polygonumate (2), along with six known drimane-type sesquiterpenes [dendocarbin L (3), (+) winterin (4), (+) fuegin (5), changweikangic acid A (6), futronolide (7), and 7-ketoisodrimenin (8)] were isolated from the whole plant of Polygonum hydropiper Linn. Their structures were determined using spectroscopic techniques. Single-crystal X-ray diffraction study on dendocarbin L (3) and 13C-NMR spectroscopic data of (+) winterin (4) are described for the first time. Compound 6 was evaluated for inhibitions of -chymotrypsin, acetylcholinesterase, and butyrylcholinesterase enzymes. © Georg Thieme Verlag KG Stuttgart · New York.

Publication Title

Planta Medica

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