Homopiperazine Pt(II) adducts with DNA bases and nucleosides: Crystal structure of [Pt^II(homopiperazine)(9-ethylguanine)2](NO3)2

Authors

Mohammad S. Ali, University of Texas Health Science Center at Houston
Edio Longoria, University of Texas Health Science Center at Houston
Teyeb Ould Ely, Rice University
Kenton H. Whitmire, Rice University
Abdul R. Khokhar, University of Texas Health Science Center at Houston

Abstract

A series of platinum(II) mono- and diadducts of the type [PtII(hmp)XCl]NO3 and [PtII(hmp)X2](NO3)2 (where hmp = homopiperazine and X = adenine, 9-ethylguanine, 7-methylguaninine, cytosine, 1-methylcytosine, or cytidine), have been synthesized and characterized by elemental analysis and by 1H, 13C, and 195Pt nuclear magnetic resonance spectroscopy. The crystal structure of diadduct [PtII(homopiperazine)(9-ethylguanine)2](NO3)2 was determined using a single crystal X-ray diffraction method. In this complex, platinum had a slightly distorted square planar geometry owing to the presence of a geometrically strained 5-membered ring. The two adjacent corners of the platinum plane were occupied by the two amino nitrogens of hmp, whereas the other two equatorial positions were occupied by two nitrogen atoms of two 9-ethylguanine. The 9-ethylguanine ligands are oriented in a head to tail fashion between 9-ethylguanine and platinum coordination plane possessing approximate C2 molecular symmetry. © 2006 Elsevier Ltd. All rights reserved.

Publication Title

Polyhedron

Recommended Citation

Ali, M., Longoria, E., Ely, T., Whitmire, K., & Khokhar, A. (2006). Homopiperazine Pt(II) adducts with DNA bases and nucleosides: Crystal structure of [Pt^II(homopiperazine)(9-ethylguanine)2](NO3)2. Polyhedron (10), 2065-2071. https://doi.org/10.1016/j.poly.2006.01.003