Ligand-free copper-catalyzed synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles
Abstract
(Chemical Equation Presented) The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles is described via intramolecular cyclization of o-bromoaryl derivatives using copper(II) oxide nanoparticles in DMSO under air. The procedure is experimentally simple, general, efficient, and free from addition of external chelating ligands. It is a heterogeneous process and the copper(II) oxide nanoparticles can be recovered and recycled without loss of activity. ©2009 American Chemical Society.
Publication Title
Journal of Organic Chemistry
Recommended Citation
Saha, P., Ramana, T., Purkait, N., Ali, M., Paul, R., & Punniyamurthy, T. (2009). Ligand-free copper-catalyzed synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles. Journal of Organic Chemistry (22), 8719-8725. https://doi.org/10.1021/jo901813g
