Oxidation of sulfides with N-bromosuccinimide in the presence of hydrated silica gel

Abstract

An efficient and highly selective procedure for oxidation of sulfides to sulfoxides with N-bromosuccinimide (NBS) in the presence of hydrated silica gel has been developed. Hydrated silica gel supplies the water necessary for decomposition of the intermediate bromosulfonium salt to the product, allowing the reaction to employ a nonaqueous media. Also, this procedure has increased the scope of the reaction by oxidizing a wider variety of sulfides, which was not possible until now. Copyright © Taylor & Francis Group, LLC.

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Synthetic Communications

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