Preparation and invitro evaluation of sustained release matrix tablets of phenytoin sodium using natural polymers

Abstract

The aim of the present study was to develop sustained release matrix tablets of phenytoin sodium an antiepileptic drug. Advantages of sustained- release tablets are that they can often be taken less frequently than instant release formulations of the same drug, and that they keep steady levels of the drug in the blood stream. The tablets were fabricated by the wet granulation method using water as granulating agent along with matrix materials like guar gum, sodium alginate, tragacanth and xanthan gum with varying percentage. The granules were evaluated for angle of repose, bulk density, compressibility index, total porosity, and drug content. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. The swelling behavior of matrix was also investigated. The granules showed satisfactory flow properties, compressibility, and drug content. The I.R spectral analysis studies confirmed no interaction between phenytoin with used natural gums. All the tablet formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters. In the further formulation development process, F8 (55% guar gum with 10% acacia), the most successful formulation of the study, exhibited satisfactory drug release and could extend the release up to 12 hours. The mechanism of drug release from all the formulations was diffusion coupled with erosion.

Publication Title

International Journal of Pharmacy and Pharmaceutical Sciences

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