6-amino-1,8-dihydroimidazo[4,5-e][1,3]diazepin-4(5H)-one, a ring expanded analogue of guanine
Abstract
The preparation of 6-amino-1,8-dihydroimidazo[4,5-e][1,3]diazepin-4(5H)-one (15), an analogue of guanine which has a seven-membered ring in place of the usual six-membered ring, is described. Cyclization to form the aminodiazepine ring involves reaction of amide and isothiourea groups in a suitably substituted imidazole precursor. The method is also shown to be applicable to the synthesis of an acyclonucleoside derivative (20).
Publication Title
Journal of the Chemical Society - Perkin Transactions 1
Recommended Citation
Bridson, P., Huang, H., & Lin, X. (1996). 6-amino-1,8-dihydroimidazo[4,5-e][1,3]diazepin-4(5H)-one, a ring expanded analogue of guanine. Journal of the Chemical Society - Perkin Transactions 1 (18), 2257-2260. https://doi.org/10.1039/p19960002257
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