Association of filaggrin variants with asthma and rhinitis: Is eczema or allergic sensitization status an effect modifier?

Authors

Ali H. Ziyab, University of South CarolinaFollow
Wilfried Karmaus, University of Memphis
Hongmei Zhang, University of MemphisFollow
John W. Holloway, University of Southampton, Faculty of Medicine
Susan E. Steck, University of South Carolina
Susan Ewart, Michigan State University
Syed Hasan Arshad, University of Southampton, Faculty of MedicineFollow

Abstract

Background: Associations of variants of the filaggrin gene, i.e. FLG with asthma and rhinitis have been shown to be modulated by eczema status. However, it is unknown whether allergic sensitization status modifies this association. The aim of this study was to determine whether FLG variants need eczema and/or allergic sensitization as a necessary component to execute adverse effects on coexisting and subsequent asthma and rhinitis.

Publication Title

International Archives of Allergy and Immunology

Recommended Citation

Ziyab, A., Karmaus, W., Zhang, H., Holloway, J., Steck, S., Ewart, S., & Arshad, S. (2014). Association of filaggrin variants with asthma and rhinitis: Is eczema or allergic sensitization status an effect modifier?. International Archives of Allergy and Immunology, 164 (4), 308-318. https://doi.org/10.1159/000365990