Base-Free Iridium-Catalyzed Hydrogenation of Esters and Lactones

Authors

Timothy P. Brewster, University of WashingtonFollow
Nomaan M. Rezayee, University of Michigan, Ann Arbor
Zuzana Culakova, University of Washington
Melanie S. Sanford, University of Michigan, Ann Arbor
Karen I. Goldberg, University of Washington

Abstract

Half-sandwich iridium bipyridine complexes catalyze the hydrogenation of esters and lactones under base-free conditions. The reactions proceed with a variety of ester and lactone substrates. Mechanistic studies implicate a pathway involving rate-limiting hydride transfer to the substrate at high pressures of H2 (≥50 bar).

Publication Title

ACS Catalysis

Recommended Citation

Brewster, T., Rezayee, N., Culakova, Z., Sanford, M., & Goldberg, K. (2016). Base-Free Iridium-Catalyzed Hydrogenation of Esters and Lactones. ACS Catalysis, 6 (5), 3113-3117. https://doi.org/10.1021/acscatal.6b00263