Base-Free Iridium-Catalyzed Hydrogenation of Esters and Lactones
Half-sandwich iridium bipyridine complexes catalyze the hydrogenation of esters and lactones under base-free conditions. The reactions proceed with a variety of ester and lactone substrates. Mechanistic studies implicate a pathway involving rate-limiting hydride transfer to the substrate at high pressures of H2 (≥50 bar).
Brewster, T., Rezayee, N., Culakova, Z., Sanford, M., & Goldberg, K. (2016). Base-Free Iridium-Catalyzed Hydrogenation of Esters and Lactones. ACS Catalysis, 6 (5), 3113-3117. https://doi.org/10.1021/acscatal.6b00263