R2* magnetic resonance imaging of the liver in patients with iron overload
Abstract
R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Fortythree patients (sickle cell anemia, n = 32; β-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion duration, 15 months, average (±SD) serum ferritin 2718 plus or minus 1994 ng/mL, and average HIC 10.9 plus or minus 6.8 mg Fe/g dry weight liver. Regions of interest were drawn and analyzed by 3 independent reviewers with excellent agreement of their measurements (intraclass correlation coefficient = 0.98). Ferritin and R2*-MRI were weakly but significantly associated (range of correlation coefficients among the 3 reviewers, 0.41-0.48; all P < .01). R2*-MRI was strongly associated with HIC for all 3 reviewers (correlation coefficients, 0.96-0.98; all P < .001). This high correlation confirms prior reports, calibrates R2*-MRI measurements, and suggests its clinical utility for predicting HIC using R2*-MRI. This study was registered at www.clinicaltrials.gov as #NCT00675038. © 2009 by The American Society of Hematology.
Publication Title
Blood
Recommended Citation
Hankins, J., McCarville, M., Loeffler, R., Smeltzer, M., Onciu, M., Hoffer, F., Li, C., Wang, W., Ware, R., & Hillenbrand, C. (2009). R2* magnetic resonance imaging of the liver in patients with iron overload. Blood, 113 (20), 4853-4855. https://doi.org/10.1182/blood-2008-12-191643
