Conversion of guanosine into its N²-methyl derivative

Authors

Peter K. Bridson, King's College LondonFollow
Wojciech Markiewicz, King's College London
Colin B. Reese, King's College London

Abstract

N2-Methylguanosine (1c) may be prepared in satisfactory yield by treating the protected guanosine derivative (5a) with diazomethane and then removing the protecting groups; (5a), which readily reacts with dimethylamine to give (5c), may be prepared from (4a) in good yield.

Publication Title

Journal of the Chemical Society, Chemical Communications

Recommended Citation

Bridson, P., Markiewicz, W., & Reese, C. (1977). Conversion of guanosine into its N²-methyl derivative. Journal of the Chemical Society, Chemical Communications (13), 447-448. https://doi.org/10.1039/C39770000447