Conversion of guanosine into its N2-methyl derivative
N2-Methylguanosine (1c) may be prepared in satisfactory yield by treating the protected guanosine derivative (5a) with diazomethane and then removing the protecting groups; (5a), which readily reacts with dimethylamine to give (5c), may be prepared from (4a) in good yield.
Journal of the Chemical Society, Chemical Communications
Bridson, P., Markiewicz, W., & Reese, C. (1977). Conversion of guanosine into its N2-methyl derivative. Journal of the Chemical Society, Chemical Communications (13), 447-448. https://doi.org/10.1039/C39770000447