Title

Conversion of guanosine into its N2-methyl derivative

Abstract

N2-Methylguanosine (1c) may be prepared in satisfactory yield by treating the protected guanosine derivative (5a) with diazomethane and then removing the protecting groups; (5a), which readily reacts with dimethylamine to give (5c), may be prepared from (4a) in good yield.

Publication Title

Journal of the Chemical Society, Chemical Communications

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