Crystal structures of a second G protein-coupled receptor: Triumphs and implications

Abstract

Long sought: The recently reported crystallographic structures of the β2-adrenergic receptor demonstrate that GPCR exhibit the strong structural conservation expected, in addition to some surprising structural differences. These structures were obtained through a number of methodological advances that are broadly applicable to studies of other GPCR. (Figure Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Publication Title

ChemMedChem

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