Dual Imaging Single Vesicle Surface Protein Profiling and Early Cancer Detection
Abstract
The first general method for the Pd-catalyzed amination of aryl tosylates and benzenesulfonates was developed utilizing ligand 1, which belongs to a new generation of biaryl monophosphine ligands. In addition, the new catalyst system for the first time enables amidation of aryl arenesulfonates and aqueous amination protocols that do not necessitate the use of cosolvents. The substrate scope has been significantly expanded to include aryl halides containing primary amides and free carboxylic acid groups. In the case of multifunctional substrates, the Pd-catalyzed amination can provide selectivity that is complementary to the Cu-catalyzed C-N bond-forming processes. Copyright © 2003 American Chemical Society.
Publication Title
ACS Applied Materials and Interfaces
Recommended Citation
Huang, X., Anderson, K., Zim, D., Jiang, L., Klapars, A., & Buchwald, S. (2022). Dual Imaging Single Vesicle Surface Protein Profiling and Early Cancer Detection. ACS Applied Materials and Interfaces https://doi.org/10.1021/acsami.2c19235
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