Orthogonal Pd- and Cu-based catalyst systems for C- and N-arylation of oxindoles
Abstract
A low-cost, automated pipetting system (auto pipet) was developed to deliver microliter volumes of aqueous solutions. This system was constructed using a single board computer, 3 D-printed parts, stepper motors, and other commercially available components. The performance of the auto pipet was found to be comparable or better than manual pipetting and a commercially available liquid handling system. Inter-day, intra-day, inter-instrumental, and intra-instrumental validation studies were performed to evaluate the accuracy and precision of liquid delivery using the auto pipet. Accuracy was determined to be from 98 to 102% with the precision, represented as the relative standard deviation, to be less than 3%. The auto pipet was further evaluated by the preparation of calibration and check standards for the determination of method detection limit, accuracy, and precision for trihalomethanes using a commercially available monitoring system. The auto pipet was also used as a digital buret to perform water hardness and water alkalinity titrations with promising results.
Publication Title
Journal of the American Chemical Society
Recommended Citation
Boppana, N., Snow, R., Simone, P., Emmert, G., & Brown, M. (2008). Orthogonal Pd- and Cu-based catalyst systems for C- and N-arylation of oxindoles. Journal of the American Chemical Society, 130 (29), 9613-9620. https://doi.org/10.1021/ja803179s
